4-BROMO-3,5-DIMETHYLPYRIDINE

Base Information

• Chemical Name: 4-BROMO-3,5-DIMETHYLPYRIDINE
• CAS No.: 201286-65-9
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.051
• Hs Code.: 2933399090
• Mol file: 201286-65-9.mol

Synonyms:4-Bromo-3,5-dimethylpyridine

Chemical Property of 4-BROMO-3,5-DIMETHYLPYRIDINE

Chemical Property:

• Boiling Point: 235.5±35.0 °C(Predicted)
• PKA: 3.81±0.10(Predicted)
• PSA: 12.89000
• Density: 1.415±0.06 g/cm3(Predicted)
• LogP: 2.46090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-3,5-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-3,5-dimethylpyridine is used in preparation of Sulfonyl Indoles and related Bicyclic compounds as modulators of LXR for treatment and prevention of LXR-mediated diseases.

Technology Process of 4-BROMO-3,5-DIMETHYLPYRIDINE

There total 4 articles about 4-BROMO-3,5-DIMETHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-bromo-3,5-dimethyl-pyridine 1-oxide (70564-92-0) → 4-bromo-3,5-dimethylpyridine (201286-65-9)

Guidance literature:

With lithium aluminium tetrahydride; titanium tetrachloride; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1002/anie.201502960

Reference yield:

3,5-dimethyl-4-nitropyridine-1-oxide (14248-66-9) + phosphorus tribromide (7789-60-8) → 4-bromo-3,5-dimethylpyridine (201286-65-9)

Guidance literature:

In toluene;

Reference yield:

3,5-Lutidine (591-22-0) → 4-bromo-3,5-dimethylpyridine (201286-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; peracetic acid / 1.17 h / 85 °C

1.2: 19 h

2.1: titanium tetrachloride; lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 °C

With peracetic acid; lithium aluminium tetrahydride; titanium tetrachloride; acetic acid; In tetrahydrofuran;

DOI:10.1002/anie.201502960

upstream raw materials:

3,5-dimethyl-4-nitropyridine-1-oxide

phosphorus tribromide

4-bromo-3,5-dimethyl-pyridine 1-oxide

3,5-Lutidine

Downstream raw materials:

3,5-dimethylpyridine-4-carbaldehyde

4-(3,5-di-tert-butyl-4-methoxyphenyl)-3,5-dimethylpyridine

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)-pyridine