Phosphorus tribromide

Base Information

• Chemical Name: Phosphorus tribromide
• CAS No.: 7789-60-8
• Molecular Formula: Br3P
• Molecular Weight: 270.686
• Hs Code.: HOSPHORUS TRIBROMIDE PRODUCT IDENTIFICATION
• European Community (EC) Number: 232-178-2
• UN Number: 1808
• UNII: 58R3866PUA
• DSSTox Substance ID: DTXSID7064869
• Nikkaji Number: J95.136F
• Wikipedia: Phosphorus tribromide,Phosphorus_tribromide
• Wikidata: Q416401
• Mol file: 7789-60-8.mol

Synonyms:tribromophosphane;Phosphorous tribromide;Tribromophosphine;Phosphorus bromide (PBr3);Phosphorous bromide;Phosphorus tribromide [UN1808] [Corrosive];phosphorum tribromide;Phosphlrus tribromide;Phosphoric tribromide;Phosphorusbromide;

Chemical Property of Phosphorus tribromide

Chemical Property:

• Appearance/Colour: colorless fuming liquid with a pungent odor
• Vapor Pressure: 0.27 psi ( 54 °C)
• Melting Point: -40 °C
• Refractive Index: n20/D 1.697(lit.)
• Boiling Point: 172.9 °C at 760 mmHg
• Flash Point: 172.9°C
• PSA: 13.59000
• Density: 2.88 g/mL at 20 °C(lit.)
• LogP: 3.39800
• Storage Temp.: -20°C
• Sensitive.: Moisture Sensitive
• Solubility.: soluble in Ether,Acetone,Chloroform
• Water Solubility.: reacts
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 269.72673
• Heavy Atom Count: 4
• Complexity: 8
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Phosphorus Tribromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-37-40-14-67
• Safety Statements: 26-45-36/37-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Phosphorus Compounds
• Canonical SMILES: P(Br)(Br)Br
• Uses: Phosphorus tribromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen. Phosphorus tribromide may be used as a reagent: In a novel protocol for synthesizing 7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, a synthetic juvenile hormone mimic of trans,trans,cis-10,11-epoxy-7-ethyl-3,11-dimethyltrideca-2,6-dienoate. To synthesize 1,2,3-diazaphosphinane, 1,2,3-thiazaphosphinine and 1,2-azaphosphole bearing a chromone ring. To synthesize 1-Bromoundec-1-ene from 10-undecen-1-ol. Phosphorus(III) bromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. It is used as a catalyst for the alpha-bromination of carboxylic acids and used as intermediates in hell-volhard-zelinsky halogenation. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen. It is also used as a fire suppression agent.

Technology Process of Phosphorus tribromide

There total 62 articles about Phosphorus tribromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

phosphorous + bromine (7726-95-6) → phosphorus tribromide (7789-60-8)

Guidance literature:

In benzene;

Reference yield:

phosphonic Acid (13598-36-2) + bromine (7726-95-6) → phosphoric acid (86119-84-8,7664-38-2) + hydrogen bromide (10035-10-6,12258-64-9) + phosphorus tribromide (7789-60-8)

Guidance literature:

In neat (no solvent); heating an excess of H3PO3 with Br2 in a sealed tube at 100 °C;;

Reference yield:

P(O)Cl2Br (13455-03-3) + phosphoric acid (86119-84-8,7664-38-2) → hydrogenchloride (7647-01-0,15364-23-5) + metaphosphoric acid + hydrogen bromide (10035-10-6,12258-64-9) + phosphorus tribromide (7789-60-8) + phosphorus trichloride (7719-12-2,52843-90-0)

Guidance literature:

In neat (no solvent); reaction starting at 60°C with evolution of gas;;

upstream raw materials:

phenyl dibromophosphite

butyl phosphorodibromidite

hydrogen bromide

Pyridine hydrobromide

Downstream raw materials:

4-aminopyridine

3,4-dimethyl-1-phenyl-1H-pyrazole

3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole

1-bromo-3-chloro-propan-2-ol

Refernces

• 1、 Lathrop, David,Eckert, Hellmut. "Chemical Disorder in Non-Oxide Chalcogenide Glasses. Site Speciation in the System Phosphorus-Selenium by Magic Angle Spinning NMR at Very High Spinning Speeds". . p. 7895 - 7902. Retrieved 1989.
• 2、 Dillon, Keith B.,Platt, Andrew W. G.. "Cyano and Thiocyanato-derivatives of the Hexachlorophosphate Ion (PCl6(1-))". . p. 1199 - 1204. Retrieved 2007/10/02.