1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

Base Information

Chemical Name:1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol
CAS No.:1292814-89-1
Molecular Formula:C₂₅H₂₆IN₅O₄
Molecular Weight:587.417
Hs Code.:

Synonyms:1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

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Chemical Property of 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

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Technology Process of 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

There total 6 articles about 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 176756-87-9
1-amino-2,5-anhydro-1-deoxy-3,4-di-O-benzyl-D-glucitol

: 18552-90-4
6-chloro-2-iodo-(9H)-purine

: 1292814-89-1
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

Guidance literature:: With triethylamine; In butan-1-ol; at 80 ℃; for 6h;
DOI:10.1016/j.ejmech.2011.01.048

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1292814-89-1
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

2: copper(l) iodide; diiodomethane; iodine; isopentyl nitrite / acetonitrile / 2 h / Reflux; Inert atmosphere

3: water; sodium hydroxide / isopropyl alcohol / 72 h / 20 °C

4: triethylamine / butan-1-ol / 6 h / 80 °C

With copper(l) iodide; diiodomethane; water; iodine; caesium carbonate; triethylamine; sodium hydroxide; isopentyl nitrite; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; butan-1-ol;
DOI:10.1016/j.ejmech.2011.01.048

Reference yield:

: 157363-84-3
1,2:5,6-dianhydro-3,4-di-O-benzyl-L-iditol

: 1292814-89-1
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(2-iodo-9H-purin-6-yl)-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; silica gel / acetonitrile / 48 h

2: hydrogen; palladium / ethyl acetate / 1.5 h / 20 °C

3: triethylamine / butan-1-ol / 6 h / 80 °C

With sodium azide; hydrogen; silica gel; palladium; triethylamine; In ethyl acetate; acetonitrile; butan-1-ol;
DOI:10.1016/j.ejmech.2011.01.048