Technology Process of 4-fluoro-1H-indol-5-amine
There total 5 articles about 4-fluoro-1H-indol-5-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: acetic acid; sodium cyanoborohydride / 16.25 h / 0 - 20 °C
2: 2 h / 20 °C
3: nitric acid; sulfuric acid / 3 h / -10 - 0 °C
4: hydrogenchloride / water / 1 h / 100 °C
5: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 7 h / 80 °C
6: iron; ammonium chloride / water; ethyl acetate / 4 h / 60 °C
With
hydrogenchloride; sulfuric acid; nitric acid; iron; sodium cyanoborohydride; ammonium chloride; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
water; ethyl acetate; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2 h / 20 °C
2: nitric acid; sulfuric acid / 3 h / -10 - 0 °C
3: hydrogenchloride / water / 1 h / 100 °C
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 7 h / 80 °C
5: iron; ammonium chloride / water; ethyl acetate / 4 h / 60 °C
With
hydrogenchloride; sulfuric acid; nitric acid; iron; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
water; ethyl acetate; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 3 h / -10 - 0 °C
2: hydrogenchloride / water / 1 h / 100 °C
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 7 h / 80 °C
4: iron; ammonium chloride / water; ethyl acetate / 4 h / 60 °C
With
hydrogenchloride; sulfuric acid; nitric acid; iron; ammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
water; ethyl acetate; benzene;
