1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride

Base Information

• Chemical Name: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride
• CAS No.: 24622-62-6
• Molecular Formula: C₁₆H₂₁NO₃*ClH
• Molecular Weight: 311.809
• Hs Code.: 2934999090
• Mol file: 24622-62-6.mol

Synonyms:Methylenedioxypyrovalerone(MDPV);Valerophenone, 3',4'-(methylenedioxy)-2-(1-pyrrolidinyl)-, hydrochloride (8CI);1-Pentanone,1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-, hydrochloride (9CI);1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride

Chemical Property:

• Melting Point: 229-234°C
• Boiling Point: 415.5 °C at 760 mmHg
• Flash Point: 205.1 °C
• PSA: 38.77000
• Density: 0.951 g/cm³
• LogP: 3.60240
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

Safty Information:

• Pictogram(s): Xi,N,T,F
• Hazard Codes: Xi,N,T,F
• Statements: 41-50-39/23/24/25-23/24/25-11
• Safety Statements: 26-39-61-45-36/37-16

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methylenedioxy pyrovalerone (MDPV) is a central nervous system

Technology Process of 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride

There total 4 articles about 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrrolidinon (616-45-5) + (+/-)-(1R*)-1-Bromo-1-(3,4-methylenedioxybenzoyl)butane (146721-06-4) → (R/S)-1-((benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one) hydrochloride (24622-62-6)

Guidance literature:

2-pyrrolidinon; (+/-)-(1R*)-1-Bromo-1-(3,4-methylenedioxybenzoyl)butane; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In diethyl ether; isopropyl alcohol;

DOI:10.1007/s00213-018-4962-0

Reference yield:

MDPV (687603-66-3) → (R/S)-1-((benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one) hydrochloride (24622-62-6)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol;

DOI:10.1002/chir.22423

Reference yield:

Methylenedioxybenzene (274-09-9) → (R/S)-1-((benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one) hydrochloride (24622-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tin(IV) chloride / dichloromethane / 3 - 10 °C

2: bromine; acetic acid / dichloromethane

3: dichloromethane / 16 h / 20 °C

With bromine; tin(IV) chloride; acetic acid; In dichloromethane;

DOI:10.1007/s00213-018-4962-0

upstream raw materials:

MDPV

2-pyrrolidinon

(+/-)-(1R*)-1-Bromo-1-(3,4-methylenedioxybenzoyl)butane

Methylenedioxybenzene

Downstream raw materials:

MDPV

Refernces

• 1、 Suzuki, Masaki,Deschamps, Jeffrey R.,Jacobson, Arthur E.,Rice, Kenner C.. "Chiral resolution and absolute configuration of the enantiomers of the psychoactive designer drug 3,4-methylenedioxypyrovalerone". . p. 287 - 293. Retrieved 2015/03/30.