(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
CAS No.:1313579-77-9
Molecular Formula:C₂₀H₂₂N₂O₃
Molecular Weight:338.406
Hs Code.:

Synonyms:(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

There total 5 articles about (S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1313579-76-8
(S)-methyl 3-methyl-2-(5-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

: 1313579-77-9
(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 16h; Reflux;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1313579-77-9
(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

2: dibenzoyl peroxide / tetrachloromethane / 80 °C

3: triethylamine / toluene / Reflux

4: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

With iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1313579-77-9
(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 16 h / Reflux

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

3: dibenzoyl peroxide / tetrachloromethane / 80 °C

4: triethylamine / toluene / Reflux

5: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

With sulfuric acid; iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;