(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
CAS No.:1313582-69-2
Molecular Formula:C₂₇H₂₆N₂O₄
Molecular Weight:442.514
Hs Code.:

Synonyms:(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

There total 6 articles about (S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1313582-69-2
(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

2: dibenzoyl peroxide / tetrachloromethane / 80 °C

3: triethylamine / toluene / Reflux

4: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

5: pyridine / dichloromethane / 16 h

With pyridine; iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1313579-77-9
(S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

: 98-88-4
benzoyl chloride

: 1313582-69-2
(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: With pyridine; In dichloromethane; for 16h;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1313582-69-2
(S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 16 h / Reflux

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

3: dibenzoyl peroxide / tetrachloromethane / 80 °C

4: triethylamine / toluene / Reflux

5: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

6: pyridine / dichloromethane / 16 h

With pyridine; sulfuric acid; iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;