2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

Base Information

Chemical Name:2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester
CAS No.:199467-17-9
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

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Chemical Property of 2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

Chemical Property:

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Technology Process of 2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

There total 2 articles about 2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 199467-17-9
2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / DMAP; EDCI / CH₂Cl₂ / 4 h / 20 °C

2.1: O₃ / CH₂Cl₂ / 0.6 h / -78 °C

3.1: CH₂Cl₂ / 1 h / -78 °C

3.2: 7.9877 g / AgNO₃ / tetrahydrofuran; H₂O / 24 h / 20 °C

With dmap; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0040-4020(03)00860-3

Reference yield:

: 199467-15-7
(4S)-4-(benzyloxycarbonylamino)-3-oxo-2-(triphenylphosphoranylidene)pentanenitrile

: 199467-17-9
2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂ / 0.6 h / -78 °C

2.1: CH₂Cl₂ / 1 h / -78 °C

2.2: 7.9877 g / AgNO₃ / tetrahydrofuran; H₂O / 24 h / 20 °C

With ozone; In dichloromethane;
DOI:10.1016/S0040-4020(03)00860-3

Reference yield:

: 199467-17-9
2-(3-benzyloxycarbonylamino-2-oxobutyrylamino)-4-methylpentanoic acid tert-butyl ester

: 158221-48-8
(3-isobutyl-7-methyl-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / CH₂Cl₂ / 0.67 h / 20 °C

2: 0.1791 g / HOBt; EDCI / CH₂Cl₂ / 2.5 h / 20 °C

3: CH₂Cl₂ / 1.5 h / 20 °C

4: 2.2192 g / diphenylphosphoryl azide; NaHCO₃ / dimethylformamide / 40 h / -15 °C

With diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00860-3