2-Bromo-7-methoxynaphthalene

Base Information

• Chemical Name: 2-Bromo-7-methoxynaphthalene
• CAS No.: 200875-36-1
• Molecular Formula: C₁₁H₉BrO
• Molecular Weight: 237.096
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID10514522
• Nikkaji Number: J3.442.812C
• Wikidata: Q82374901
• Mol file: 200875-36-1.mol

Synonyms:2-Bromo-7-methoxynaphthalene;200875-36-1;Naphthalene, 2-bromo-7-methoxy-;MFCD17012538;Naphthalene,2-bromo-7-methoxy-(9ci);Naphthalene, 2-bromo-7-methoxy- (9CI);2-bromo-7-methoxy-naphthalene;SCHEMBL3138744;DTXSID10514522;JOFOVYQPOOUQHX-UHFFFAOYSA-N;AMY42366;AKOS024106670;CS-13274;SY027765;CS-0040493;FT-0749554;W18403;A903215

Chemical Property of 2-Bromo-7-methoxynaphthalene

Chemical Property:

• Melting Point: 97.5-98 °C(Solv: ethanol (64-17-5))
• Boiling Point: 324.7±15.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.447±0.06 g/cm3(Predicted)
• LogP: 3.61090
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 235.98368
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-7-methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=CC(=C2)Br

Technology Process of 2-Bromo-7-methoxynaphthalene

There total 4 articles about 2-Bromo-7-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-bromonaphthalen-2-ol (116230-30-9) + dimethyl sulfate (77-78-1) → 2-bromo-7-methoxy-naphthalene (200875-36-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 24h;

DOI:10.1002/cmdc.201800158

Reference yield: 96.0%

7-bromonaphthalen-2-ol (116230-30-9) + methyl iodide (74-88-4) → 2-bromo-7-methoxy-naphthalene (200875-36-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 72h;

Reference yield:

2,7-Dihydroxynaphthalene (582-17-2) → 2-bromo-7-methoxy-naphthalene (200875-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; bromine / acetonitrile / 1.5 h / 0 - 250 °C

2: potassium carbonate / acetone / 10 h / Reflux; Inert atmosphere

With bromine; potassium carbonate; triphenylphosphine; In acetone; acetonitrile;

DOI:10.1016/j.dyepig.2014.04.004

upstream raw materials:

7-bromonaphthalen-2-ol

methyl iodide

2,7-Dihydroxynaphthalene

dimethyl sulfate

Downstream raw materials:

1-phenyl-3,3-dimethyl-9'-(9H-carbazol-9-yl)-spiroindolinenaphthoxadine