(3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

Base Information

• Chemical Name: (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid
• CAS No.: 1021435-07-3
• Molecular Formula: C₃₁H₄₁N₃O₇
• Molecular Weight: 567.682

Synonyms:(3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

Chemical Property of (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

Chemical Property:

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Useful:

Technology Process of (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid

There total 5 articles about (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate (1021435-06-2) → (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1(23),17,19,21,24-pentaene-5-carboxylic acid (1021435-07-3)

Guidance literature:

ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;

With potassium hydrogensulfate; In tetrahydrofuran; ethanol; water;

Reference yield:

C17H19BrN2O4 (924365-09-3) → (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1(23),17,19,21,24-pentaene-5-carboxylic acid (1021435-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

2: Zhan 1b metathesis catalyst / dichloromethane

3: palladium on carbon; hydrogen

4: ethanol; lithium hydroxide / tetrahydrofuran

With ethanol; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

Reference yield:

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid (914841-18-2) → (3R,5S,8S)-8-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1(23),17,19,21,24-pentaene-5-carboxylic acid (1021435-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

2: Zhan 1b metathesis catalyst / dichloromethane

3: palladium on carbon; hydrogen

4: ethanol; lithium hydroxide / tetrahydrofuran

With ethanol; palladium on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml1002426

upstream raw materials:

ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

C₁₇H₁₉BrN₂O₄

(2S)-cyclohexyl({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetic acid

ethyl (4R)-4-[(7-bromo-6-methoxyisoquinolin-1-yl)oxy]-1-[(2S)-2-cyclohexyl-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)acetyl]-L-prolinate

Downstream raw materials:

diethyl [1-({[(3R,5S,8S)-cyclohexyl-18-methoxy-13,13-dimethyl-7,10-dioxo-2,11-dioxa-6,9,23-triazatetracyclo[15.6.2.1~3,6~.0~20,24~]hexacosa-1⁽²³⁾,17,19,21,24-pentaen-5-yl]carbonyl}amino)-2-vinylcyclopropyl]phosphonate

C₄₀H₅₃N₅O₉S

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