3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

Base Information

Chemical Name:3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]
CAS No.:1036637-24-7
Molecular Formula:C₃₈H₄₄N₄O₉
Molecular Weight:700.789
Hs Code.:

Synonyms:3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

Suppliers and Price of 3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

Chemical Property:

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Technology Process of 3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

There total 2 articles about 3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 123639-61-2
Fmoc-L-glutamic acid-g-benzyl ester

: 35661-40-6
N-Fmoc L-Phe

: 3128-06-1
5-ketohexanoic acid

: 1036637-24-7
3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

Guidance literature:: Multistep reaction.;
DOI:10.1016/j.tetlet.2008.03.103

Reference yield:

: 2-chlorotrityl resin

: 123639-61-2
Fmoc-L-glutamic acid-g-benzyl ester

: 35661-40-6
N-Fmoc L-Phe

: 3128-06-1
5-ketohexanoic acid

: 1036637-24-7
3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

Guidance literature:: 2-chlorotrityl resin; N-Fmoc L-Phe; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Microwave irradiation;

With piperidine; In N,N-dimethyl-formamide; at 50 ℃; for 0.05h; Microwave irradiation;

Fmoc-L-glutamic acid-g-benzyl ester; 5-ketohexanoic acid;
DOI:10.1016/j.tet.2014.03.058

Reference yield: 84.0%

: 1036637-24-7
3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycine]

: 87906-06-7
3-aminopropyl 2-acetamido-2-deoxy-β-D-glucopyranoside

: 1256846-95-3
3-[N-(5-oxohexanoyl)-L-phenylalanyl-L-glutamyl-O-benzyl-L-phenylalanyl-L-glycinyl]-aminopropyl 2-acetamido-2-deoxy-β-D-glucopyranoside

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ja106955j