2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)

Base Information

• Chemical Name: 2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)
• CAS No.: 20090-58-8
• Molecular Formula: C5H6 Cl N3
• Molecular Weight: 143.576
• Hs Code.: 2933599090
• Mol file: 20090-58-8.mol

Synonyms:Pyrimidine,2-amino-4-chloro-5-methyl- (8CI); 4-Chloro-2-amino-5-methylpyrimidine

Chemical Property of 2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.000311mmHg at 25°C
• Melting Point: 184-185℃
• Refractive Index: 1.599
• Boiling Point: 320.8°C at 760 mmHg
• PKA: 3.99±0.10(Predicted)
• Flash Point: 147.8°C
• PSA: 51.80000
• Density: 1.349g/cm³
• LogP: 1.60180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-methylpyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)

There total 1 articles about 2-Pyrimidinamine, 4-chloro-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-5-methylpyrimidine (1780-31-0) → 4-chloro-5-methylpyrimidin-2-yl-amine (20090-58-8) + 2-chloro-4-amino-5-methylpyrimidine (14394-70-8)

Guidance literature:

With ammonia; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 100 ℃; for 0.25h; Irradiation; CEM discover microwave at 100W;

Reference yield: 69.0%

4-chloro-5-methylpyrimidin-2-yl-amine (20090-58-8) + ethyl acetate (141-78-6) + 3-[(4-methoxyphenyl)methoxy]-2,2-dimethyl-propan-1-ol (446264-36-4) → N-(4-(3-((4-methoxybenzyl)oxy)-2,2-dimethylpropoxy)-5-methylpyrimidin-2-yl)acetamide

Guidance literature:

4-chloro-5-methylpyrimidin-2-yl-amine; 3-[(4-methoxyphenyl)methoxy]-2,2-dimethyl-propan-1-ol; With sodium hydride; In 1,4-dioxane; mineral oil; at 60 ℃; for 23h;

ethyl acetate; In water;

DOI:10.1016/j.bmcl.2016.02.026

Reference yield: 58.0%

4-chloro-5-methylpyrimidin-2-yl-amine (20090-58-8) + C29H31N3O5S → C34H36N6O5S

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acschembio.9b00490

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

Downstream raw materials:

tert-butyl 3-(2-amino-5-methylpyrimidin-4-yl)benzoate

tert-butyl 4-(2-amino-5-methylpyrimidin-4-yl)benzoate

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