4-Amino-2-chloro-5-methylpyrimidine

Base Information

• Chemical Name: 4-Amino-2-chloro-5-methylpyrimidine
• CAS No.: 14394-70-8
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.576
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID80401713
• Nikkaji Number: J2.269.060D
• Wikidata: Q72434540
• Mol file: 14394-70-8.mol

Synonyms:14394-70-8;4-Amino-2-chloro-5-methylpyrimidine;2-chloro-5-methylpyrimidin-4-amine;4-PYRIMIDINAMINE, 2-CHLORO-5-METHYL-;MFCD02683249;4-Amino-2-chloro-5-methylpyrimidine, Technical grade >80%;4-Amino-2-chloro-5-methylpyrimidine, Technical grade >80per cent;2-chloro-4-amino-5-methylpyrimidine;6-Amino-2-Chloro-5-Methyl pyrimidine;2-CHLORO-5-METHYL-PYRIMIDIN-4-YLAMINE;SCHEMBL264246;DTXSID80401713;ZCQWIJBRCXQUNP-UHFFFAOYSA-N;2-Chlor-4-amino-5-methylpyrimidin;2-Chloro-5-methyl-4-pyrimidinamine;AKOS006277765;AC-7571;CS-W002966;PB10226;2-chloro -5-methyl-pyrimidin-4-ylamine;DS-10879;SY002998;AM20080333;FT-0649015;4-amino-2-chloro-5-methylpyrimidine, AldrichCPR;SR-01000654153;SR-01000654153-1;W-205601

Chemical Property of 4-Amino-2-chloro-5-methylpyrimidine

Chemical Property:

• Appearance/Colour: Off-white crystals
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 232-235 °C
• Refractive Index: 1.6
• Boiling Point: 334.875 °C at 760 mmHg
• PKA: 2.78±0.10(Predicted)
• Flash Point: 156.327 °C
• PSA: 51.80000
• Density: 1.35 g/cm³
• LogP: 1.60180
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Ethyl Acetae, Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 143.0250249
• Heavy Atom Count: 9
• Complexity: 98.2

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-chloro-5-methylpyrimidine,Technicalgrade>80% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(N=C1N)Cl
• Uses: Contains up to 20% 4-Chloro-5-methyl-4-pyrimidinamine

Technology Process of 4-Amino-2-chloro-5-methylpyrimidine

There total 2 articles about 4-Amino-2-chloro-5-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-5-methylpyrimidine (1780-31-0) → 4-chloro-5-methylpyrimidin-2-yl-amine (20090-58-8) + 2-chloro-4-amino-5-methylpyrimidine (14394-70-8)

Guidance literature:

With ammonia; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 100 ℃; for 0.25h; Irradiation; CEM discover microwave at 100W;

Reference yield:

→ 2-chloro-4-amino-5-methylpyrimidine (14394-70-8)

Guidance literature:

2-Chlor-7-methylpyrin, NaOH S.1858;

Reference yield: 99.0%

1-bromo-3-(tertbutyl)benzene (3972-64-3) + 2-chloro-4-amino-5-methylpyrimidine (14394-70-8) → 2-chloro-N4-[3-(1,1-dimethylethyl)phenyl]-5-methylpyrimidin-4-amine (936092-60-3)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 20h; Heating / reflux;

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

Downstream raw materials:

5-methyl-N₂-3-(3-(morpholinomethyl)phenyl)pyrimidine-2,4-diamine

(2-chloro-5-methyl-pyrimidin-4-yl)-(3-chloro-phenyl)-amine

5-methyl-N₂-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,4-diamine

2-chloro-5-methyl-N-(3,5-dimethylphenyl)pyrimidine-4-amine