3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Base Information

• Chemical Name: 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one
• CAS No.: 77211-47-3
• Molecular Formula: C₁₆H₂₀N₂O₄
• Molecular Weight: 304.346
• Mol file: 77211-47-3.mol

Synonyms:3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Chemical Property of 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one

There total 3 articles about 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one (77211-46-2) + methyl iodide (74-88-4) → 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one (77211-47-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

DOI:10.1021/jm00143a012

Reference yield:

8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one (5053-14-5) → 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one (77211-47-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol / 16 h / 50 °C

2: 81 percent / sodium bicarbonate / H₂O / 0 °C

3: 94 percent / sodium hydride / dimethylformamide / 1 h / 60 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00143a012

Reference yield:

1-oxa-3,8-diazaspiro[4.5]-decan-2-one (5052-95-9) → 3-methyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one (77211-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / sodium bicarbonate / H₂O / 0 °C

2: 94 percent / sodium hydride / dimethylformamide / 1 h / 60 °C

With sodium hydride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00143a012

upstream raw materials:

8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one

methyl iodide

1-oxa-3,8-diazaspiro[4.5]-decan-2-one

8-Benzyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

Downstream raw materials:

(R)-3-methyl-8-<3-(2-methoxyphenoxy)-2-hydroxypropyl>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

(S)-3-methyl-8-<3-(2-methoxyphenoxy)-2-hydroxypropyl>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

3-methyl-8-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one