tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

Base Information

Chemical Name:tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate
CAS No.:1234286-77-1
Molecular Formula:C₂₉H₃₆BrNO₅
Molecular Weight:558.513
Hs Code.:

Synonyms:tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

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Chemical Property of tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

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Technology Process of tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

There total 19 articles about tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1176327-37-9
2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl 4-methylbenzenesulfonate

: 1232867-09-2
tert-butyl [2-bromo-5-(piperidin-4-ylmethyl)phenoxy]acetate

: 1234286-77-1
tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 55 - 60 ℃; for 19.5h;

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1234286-77-1
tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

1.2: 6 h / 90 °C / Inert atmosphere

1.3: 1.67 h / 20 - 25 °C / water cooling

2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3.5 h / 25 °C

2.2: 0.33 h / 20 °C

3.1: hydrogen bromide / toluene; water / 2 h / 65 - 70 °C

4.1: toluene / 3.5 h / Reflux

5.1: potassium carbonate / isopropyl alcohol / Reflux

6.1: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 3 h / 15 - 20 °C / 760.05 Torr

7.1: hydrogenchloride / isopropyl alcohol; water / 4.08 h / 55 - 60 °C

8.1: potassium carbonate / 1,4-dioxane; water / 20 °C

9.1: potassium carbonate / acetonitrile / 72 h / 20 °C

10.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

11.1: potassium carbonate / acetonitrile / 19.5 h / 55 - 60 °C

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen bromide; hydrogen; potassium carbonate; 5% rhodium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1147886-95-0
(4-bromo-3-(2-methoxyethoxy)phenyl)methanol

: 1234286-77-1
tert-Butyl [2-bromo-5-({1-[2-(4-oxo-3,4-dihydro-2H-chromen-6-yl)ethyl]piperidin-4-yl}methyl)phenoxy]acetate

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / trimethylamine hydrochloride / toluene / 2.5 h / 5 °C

2: lithium bromide / tetrahydrofuran / 1 h / Reflux

3: toluene / 3.5 h / Reflux

4: potassium carbonate / isopropyl alcohol / Reflux

5: hydrogen / 5% rhodium-on-charcoal / ethyl acetate / 3 h / 15 - 20 °C / 760.05 Torr

6: hydrogenchloride / isopropyl alcohol; water / 4.08 h / 55 - 60 °C

7: potassium carbonate / 1,4-dioxane; water / 20 °C

8: potassium carbonate / acetonitrile / 72 h / 20 °C

9: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

10: potassium carbonate / acetonitrile / 19.5 h / 55 - 60 °C

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; lithium bromide; 5% rhodium-on-charcoal; trimethylamine hydrochloride; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;