(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

Base Information

Chemical Name:(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid
CAS No.:914800-47-8
Molecular Formula:C₂₃H₂₀O₄S₂
Molecular Weight:424.541
Hs Code.:

Synonyms:(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

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Chemical Property of (E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

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Technology Process of (E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

There total 3 articles about (E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 914800-41-2
(E)-2-(3-Bromo-phenyl)-3-(4-methanesulfonyl-phenyl)-acrylic acid

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 914800-47-8
(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 16h; Heating;
DOI:10.1016/j.bmc.2006.08.008

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 914800-47-8
(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 18 percent / triethylamine; acetic anhydride / 16 h / 90 °C

2: 67 percent / Na₂CO₃ / tetrakis(triphenylphosphine)palladium / H₂O; 1,2-dimethoxy-ethane / 16 h / Heating

With acetic anhydride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; 1: Perkin condensation / 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.008

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 914800-47-8
(E)-3-(4-methanesulfonylphenyl)-2-[3-(4-methylsulfanylphenyl)phenyl]acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 18 percent / triethylamine; acetic anhydride / 16 h / 90 °C

2: 67 percent / Na₂CO₃ / tetrakis(triphenylphosphine)palladium / H₂O; 1,2-dimethoxy-ethane / 16 h / Heating

With acetic anhydride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; 1: Perkin condensation / 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.008