3-(m-benzoyl-phenyl)-propionic acid

Base Information

• Chemical Name: 3-(m-benzoyl-phenyl)-propionic acid
• CAS No.: 41652-24-8
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 41652-24-8.mol

Synonyms:3-(m-benzoyl-phenyl)-propionic acid

Chemical Property of 3-(m-benzoyl-phenyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(m-benzoyl-phenyl)-propionic acid

There total 3 articles about 3-(m-benzoyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

carbon monoxide (201230-82-2) + 3-ethynylbenzophenone (69355-34-6) → ketoprofen (22071-15-4,22161-86-0) + 3-(m-benzoyl-phenyl)-propionic acid (41652-24-8)

Guidance literature:

With potassium hydroxide; polyethylene glycol (PEG-400); potassium cyanide; nickel cyanide; cobalt(II) chloride; In toluene; at 90 ℃; for 24h; under 760 Torr;

DOI:10.1016/S0040-4039(00)74325-5

Reference yield:

bromobenzene (108-86-1,52753-63-6) + carbon monoxide (201230-82-2) + 3-vinylphenylboronic acid (15016-43-0) → ketoprofen (22071-15-4,22161-86-0) + 3-(m-benzoyl-phenyl)-propionic acid (41652-24-8)

Guidance literature:

bromobenzene; carbon monoxide; 3-vinylphenylboronic acid; With N,N,N,N,-tetramethylethylenediamine; palladium diacetate; catacxium A; In toluene; at 80 ℃; for 24h; under 1875.19 Torr; Inert atmosphere;

carbon monoxide; With hydrogenchloride; water; In 1,4-dioxane; toluene; at 100 ℃; for 20h; under 30003 Torr; Inert atmosphere;

DOI:10.1002/adsc.200800415

Reference yield:

→ 3-(m-benzoyl-phenyl)-propionic acid (41652-24-8)

Guidance literature:

durch Decarbox. d. entspr. Malons.;

upstream raw materials:

carbon monoxide

3-ethynylbenzophenone

bromobenzene

3-vinylphenylboronic acid

Refernces

• 1、 Lee, Jong-Tae,Alper, Howard. "DIRECT, REGIOSELECTIVE HYDROCARBOXYLATION OF ALKYNES TO SATURATED ACIDS BY COBALT AND NICKEL CATALYSTS UNDER PHASE TRANSFER CONDITIONS". . p. 1769 - 1770. Retrieved 2007/10/02.