4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide

Base Information

• Chemical Name: 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide
• CAS No.: 1435909-42-4
• Molecular Formula: C₁₁H₁₄Cl₂N₄S
• Molecular Weight: 305.231
• Mol file: 1435909-42-4.mol

Synonyms:4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide

Chemical Property of 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide

There total 3 articles about 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(3,4-dichloro)phenylpiperazine (57260-67-0) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide (1435909-42-4)

Guidance literature:

1-(3,4-dichloro)phenylpiperazine; 1,1'-Thiocarbonyldiimidazole; In dichloromethane; at 20 ℃; for 24h;

With hydrazine hydrate; for 2h; Reflux;

DOI:10.1016/j.jphotobiol.2019.111585

Reference yield: 68.0%

C14H14Cl2N4S → 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide (1435909-42-4)

Guidance literature:

With hydrazine hydrate; for 2h; Reflux;

DOI:10.1016/j.ejmech.2019.03.027

Reference yield:

1-(3,4-dichloro)phenylpiperazine (57260-67-0) → 4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide (1435909-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C

2: hydrazine hydrate / 2 h / Reflux

With hydrazine hydrate; In dichloromethane;

DOI:10.1016/j.ejmech.2019.03.027

upstream raw materials:

1-(3,4-dichloro)phenylpiperazine

1,1'-Thiocarbonyldiimidazole

Downstream raw materials:

(Z)-N’-(5-chloro-2-oxoindolin-3-ylidene)-4-(3,4-dichlorophenyl)piperazine-1-carbothiohydrazide