5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

Base Information

Chemical Name:5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione
CAS No.:1383452-46-7
Molecular Formula:C₁₃H₉F₃N₄OS
Molecular Weight:326.302
Hs Code.:

Synonyms:5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

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Chemical Property of 5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

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Technology Process of 5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

There total 7 articles about 5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1383452-45-6
1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbohydrazide

: 1383452-46-7
5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

Guidance literature:: With potassium hydroxide; In methanol; at 65 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.03.056

Reference yield: 91.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1383452-45-6
1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbohydrazide

: 1383452-46-7
5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

Guidance literature:: With potassium hydroxide; In methanol; at 0 - 65 ℃; Inert atmosphere;
DOI:10.1002/jhet.1766

Reference yield:

: 1383452-43-4
sodium (Z)-3-methoxycarbonyl-3-oxo-1-(4-trifluoromethyl)phenyl-propen-1-olate

: 1383452-46-7
5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 1 h / 105 °C / Inert atmosphere

2: hydrazine hydrate / methanol / 2 h / 100 °C / Inert atmosphere

3: potassium hydroxide / methanol / 65 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; potassium hydroxide; In methanol;
DOI:10.1016/j.ejmech.2012.03.056