methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Base Information

Chemical Name:methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate
CAS No.:1632322-77-0
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Suppliers and Price of methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

There total 5 articles about methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

: 294177-74-5
C₁₉H₁₉NO₃

: 1632322-78-1
(S)-methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

: 1632322-77-0
methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Guidance literature:: 2,4-dimethyl-3-ethyl-pyrrole; With aluminum (III) chloride; In dichloromethane; at 25 ℃; Inert atmosphere;

C₁₉H₁₉NO₃; In dichloromethane; at 25 ℃; Overall yield = 65 %; Overall yield = 120 mg; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 294177-74-5
C₁₉H₁₉NO₃

: 1632324-67-4
C₈H₁₃AlCl₃N

: 1632322-78-1
(S)-methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

: 1632322-77-0
methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Guidance literature:: In dichloromethane; at 25 ℃; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 1632322-78-1
(S)-methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

: 1632322-77-0
methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / -20 - -10 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With aluminum (III) chloride; triethylamine; In tetrahydrofuran; dichloromethane; 2.1: |Friedel-Crafts Alkylation / 2.2: |Friedel-Crafts Alkylation;
DOI:10.1055/s-0033-1341275