3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

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Chemical Name:3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester
CAS No.:590402-17-8
Molecular Formula:C₄₁H₄₇ClN₄O₉
Molecular Weight:775.299
Hs Code.:

Synonyms:3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

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Chemical Property of 3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

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Technology Process of 3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

There total 6 articles about 3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 51458-31-2
3-(4-hydroxyphenyl)propionic acid tert-butyl ester

: 590401-98-2
[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetic acid 2-(2-hydroxyethoxy)ethyl ester

: 590402-17-8
3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1039/b302239k

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 590402-17-8
3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / diethyl azodicarboxylate; Ph₃P / toluene / 0.5 h / 80 °C

2: 79 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 45 °C

3: 81 percent / diethyl azodicarboxylate; Ph₃P / toluene / 120 h / 20 °C

4: 53 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 5 h / 20 °C

With lithium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 1: Mitsunobu alkylation / 3: Mitsunobu alkylation / 4: Mitsunobu alkylation;
DOI:10.1039/b302239k

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 590402-17-8
3-{4-[2-(2-{2-[4-(2-{[4-(2-chloro-4-nitrophenylazo)phenyl]ethylamino}ethoxy)phenyl]acetoxy}ethoxy)ethoxy]phenyl}propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbonyldiimidazole / dimethylformamide / 48 h / 40 °C

1.2: 65 percent / DBU / dimethylformamide / 2 h / 65 °C

2.1: 53 percent / diethyl azodicarboxylate; Ph₃P / CH₂Cl₂ / 5 h / 20 °C

With triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide; 2.1: Mitsunobu alkylation;
DOI:10.1039/b302239k