N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide

Base Information

• Chemical Name: N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide
• CAS No.: 1527494-49-0
• Molecular Formula: C₂₇H₂₅BrFNO₂
• Molecular Weight: 494.403
• Mol file: 1527494-49-0.mol

Synonyms:N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide

Chemical Property of N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide

There total 3 articles about N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-(tert-butyl)phenoxy)-2-iodobenzene (1527494-35-4) + N-(2-bromo-4-fluorophenyl)-N-(prop-2-yn-1-yl)acetamide (1527494-44-5) → N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide (1527494-49-0)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammonium acetate; In 1,4-dioxane; at 60 ℃; for 1h;

Reference yield:

4-tert-butyl-1-(2-aminophenoxy)benzene (3169-73-1) → N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide (1527494-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 2.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; tetrabutylammonium acetate / 1,4-dioxane / 1 h / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammonium acetate; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In 1,4-dioxane; water; acetonitrile; 2: |Sonogashira Cross-Coupling;

Reference yield:

N-(2-bromo-4-fluorophenyl)acetamide (1009-22-9) → N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide (1527494-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; triethylbutylammonium chloride / toluene; tetrahydrofuran / 20 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; tetrabutylammonium acetate / 1,4-dioxane / 1 h / 60 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammonium acetate; triethylbutylammonium chloride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; toluene; 2: |Sonogashira Cross-Coupling;

upstream raw materials:

1-(4-(tert-butyl)phenoxy)-2-iodobenzene

N-(2-bromo-4-fluorophenyl)-N-(prop-2-yn-1-yl)acetamide

4-tert-butyl-1-(2-aminophenoxy)benzene

N-(2-bromo-4-fluorophenyl)acetamide