1009-22-9

Basic information

• Product Name: 2'-Bromo-4'-fluoroacetanilide
• Synonyms: N-(2-Bromo-4-fluoro-phenyl)acetamide;2'-BROMO-4'-FLUOROACETANILIDE;2-BROMO-4-FLUOROACETANILIDE;2?bromo-4?fluorophenyl acetamide;2'-Bromo-4'-fluoroacetanilide 97%;2'-Bromo-4'-fluoroacetanilide97%;2-BROMO-4-FLUOROACETANILIDE 99+%;N-Acetyl 2-bromo-4-fluoroaniline
• CAS NO: 1009-22-9
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232.05
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 1009-22-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 117-119 °C(lit.)
• Boiling Point: 337.5 °C at 760 mmHg
• Flash Point: 157.9 °C
• Appearance: /
• Density: 1.623 g/cm³
• Vapor Pressure: 0.00449mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 13.17±0.70(Predicted)
• BRN: 2803940
• CAS DataBase Reference: 2'-Bromo-4'-fluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Bromo-4'-fluoroacetanilide(1009-22-9)
• EPA Substance Registry System: 2'-Bromo-4'-fluoroacetanilide(1009-22-9)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1009-22-9(Hazardous Substances Data)

Usage

General Description

2'-Bromo-4'-fluoroacetanilide is a chemical compound that is made up of a fluorine atom and a bromine atom attached to a acetanilide group. It is commonly used in organic synthesis and pharmaceutical research as an intermediate compound. The presence of the bromine and fluorine atoms in the molecule make it useful for introducing specific chemical functionalities into other compounds during synthesis. Additionally, the acetanilide group provides a stable and versatile structure for further chemical modifications. Overall, 2'-Bromo-4'-fluoroacetanilide is a valuable chemical building block for the creation of new pharmaceuticals and other organic compounds.

InChI:InChI=1/C7H3FN2O2/c8-6-2-1-5(4-9)3-7(6)10(11)12/h1-3H

Upstream product

• 1003-98-1 2-bromo-4-fluoroaniline 
• 75-36-5 acetyl chloride 
• 351-83-7 4'-fluoroacetanilide 
• 371-40-4 4-fluoroaniline 
• 108-24-7 acetic anhydride 
• 90493-85-9 N-(2-bromophenyl)-N-hydroxyacetamide 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 1003-98-1 2-bromo-4-fluoroaniline 
• 399-73-5 6-fluoro-2-methylbenzo[d]thiazole 
• 41192-31-8 5-fluoro-2,3-dihydro-1-methylindol-2-one 
• 1527494-47-8 N-(2-bromo-4-fluorophenyl)-N-(3-(2-phenoxyphenyl)prop-2-yn-1-yl)acetamide 
• 1527494-49-0 N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide 
• 1527494-44-5 N-(2-bromo-4-fluorophenyl)-N-(prop-2-yn-1-yl)acetamide 
• 1356388-72-1 2-(2-acetamido-5-fluorophenyl)pyridine 1-oxide 
• 877179-01-6 N-[4-fluoro-2-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl]-acetamide 
• 846060-67-1 N-(4-fluoro-2-pyridin-4-yl-phenyl)acetamide 
• 1041143-98-9 3,6-difluoro-9H-carbazole 
• 38520-78-4 6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

4 - Fluorine substituted aryl amine compound and synthesis method thereof

The invention discloses a synthesis method of 4 -fluorine substituted aryl amine compound, which comprises the following steps: 1) taking acyl-protected phenylhydroxylamine as a substrate, and generating 4 -fluorine substituted aniline compound under basic conditions by taking sulfonyl fluoride as a fluorine source in a polar solvent. 2) The deprotection is carried out under dilute acid conditions or Pd by catalytic hydrogenation to give the 4 - fluorine-substituted aryl amine compound. 4 - Fluorine substituted aniline compounds which are synthesized by the invention greatly increase the lipophilic property due to the introduction of fluorine atoms, and can be widely applied to preparation of fluorine-containing drugs and pesticide and dye intermediates. , The adopted raw materials are industrial products, are cheap and easily available, and are commercially available. 4 - Fluoroaryl aniline prepared by the method is high in yield, and the product with the purity 90% can be obtained in a yield of more than ≥ 99%. The method is simple to operate and low in cost, is very suitable for industrialization, and can be widely popularized and used.

Nickel(II)- And Silver(I)-Catalyzed C-H Bond Halogenation of Anilides and Carbamates

ortho -C-H bond halogenation of anilides and N -aryl carbamates using easily available N -halosuccinimides (NXS) as the active halogenation reagent in the presence of nickel or silver catalyst has been developed. This method provides a new approach to 2-haloanilides and carbamates, which may serve as starting materials for the synthesis of pharmaceutically and biologically active compounds.