p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside

Base Information

• Chemical Name: p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside
• CAS No.: 1067674-45-6
• Molecular Formula: C₃₅H₄₈O₄SSi
• Molecular Weight: 592.915
• Mol file: 1067674-45-6.mol

Synonyms:p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside

Chemical Property of p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside

There total 1 articles about p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H36O4SSi (1131611-85-2) + benzyl bromide (100-39-0) → p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside (1067674-45-6)

Guidance literature:

C₂₁H₃₆O₄SSi; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1021/jo801408x

Reference yield:

p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside (1067674-45-6) → 5-triisopropylsilyl-2,3-O-benzyl-D-ribose

Guidance literature:

With N-Bromosuccinimide; water; In acetone; at -20 ℃; for 2h;

DOI:10.1021/acs.orglett.8b01725

Reference yield:

p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside (1067674-45-6) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2,3-di-O-benzyl-5-O-triisopropanylsilyl-β-D-ribofuranoside (1067674-95-6) + benzyl 2,3-di-O-benzyl-5-O-triisopropanylsilyl-α-D-ribofuranoside (476621-15-5)

Guidance literature:

p-tolyl 2,3-di-O-benzyl-1-thio-5-O-triisopropylsilyl-β-D-ribofuranoside; benzyl alcohol; With strontium(II) carbonate; silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.25h; Molecular sieve;

With p-toluolsulfenyl bromide; In dichloromethane; 1,2-dichloro-ethane; at 0 ℃; for 0.0166667 - 0.25h; optical yield given as %de;

DOI:10.1021/jo801408x

upstream raw materials:

C₂₁H₃₆O₄SSi

benzyl bromide

Downstream raw materials:

propargyl 2,3-di-O-benzyl-5-O-triisopropanylsilyl-α-D-ribofuranoside

propargyl 2,3-di-O-benzyl-5-O-triisopropylsilyl-β-D-ribofuranoside

benzyl 2,3-di-O-benzyl-5-O-triisopropanylsilyl-β-D-ribofuranoside

benzyl 2,3-di-O-benzyl-5-O-triisopropanylsilyl-α-D-ribofuranoside