ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Base Information

• Chemical Name: ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate
• CAS No.: 1207454-29-2
• Molecular Formula: C₂₂H₂₁N₃O₃
• Molecular Weight: 375.427
• Mol file: 1207454-29-2.mol

Synonyms:ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Chemical Property of ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

There total 5 articles about ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

1-methylimidazole-5-carbaldehyde (39021-62-0) + (E)-4-(benzylideneamino)isobenzofuran-1(3H)-one (1207452-81-0) + sodium ethanolate (141-52-6) → ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-29-2)

Guidance literature:

In ethanol; Ethyl propionate; at 0 - 20 ℃;

Reference yield: 23.0%

(E)-4-(benzylideneamino)isobenzofuran-1(3H)-one (1207452-81-0) + sodium ethanolate (141-52-6) + Ethyl propionate (105-37-3,20741-13-3) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-29-2)

Guidance literature:

In ethanol; at 0 - 20 ℃; for 3h;

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → ethyl 3-(1-methyl-1H-imidazol-5-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: methanol / Reflux

4.1: ethanol / 3 h / 0 - 20 °C

With sodium tetrahydroborate; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate;

upstream raw materials:

1-methylimidazole-5-carbaldehyde

(E)-4-(benzylideneamino)isobenzofuran-1(3H)-one

sodium ethanolate

3-nitrophthalic acid anhydride

Downstream raw materials:

9-(1-methyl-1H-imidazol-5-yl)-8-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one