C₉H₉N₃O₂

Base Information

• Chemical Name: C₉H₉N₃O₂
• CAS No.: 1246520-77-3
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.189
• Mol file: 1246520-77-3.mol

Synonyms:C₉H₉N₃O₂

Chemical Property of C₉H₉N₃O₂

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

3-(1H-Pyrazolo[3,4-b]pyridin-3-yl)propanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₉N₃O₂

There total 8 articles about C₉H₉N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H7N3O2 (1246520-76-2) → C9H9N3O2 (1246520-77-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → C9H9N3O2 (1246520-77-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: Cooling with ice

6.1: trifluoroacetic acid / 16 h / Reflux

7.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

With water; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → C9H9N3O2 (1246520-77-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: trifluoroacetic acid / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

With water; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-3-carbaldehydepyridine

3-iodo-1H-pyrazolo[3,4-b]pyridine

3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

C₁₇H₁₅N₃O₃

Downstream raw materials:

C₁₈H₁₈N₄O₃

C₂₀H₂₂N₄O₄

C₂₁H₂₅N₅O₄

C₂₄H₃₁N₅O₄