N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852661-64-4
Molecular Formula:C₃₀H₄₂FN₇O₂
Molecular Weight:551.708
Hs Code.:

Synonyms:N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Chemical Property of N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Technology Process of N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 13 articles about N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 852661-64-4
N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: tetrahydrofuran / 16 h / 0 - 20 °C

3: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 25 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 2 h / 25 °C / Heating / reflux

5: hydrogen / palladium dihydroxide / methanol / 4 h / 2585.81 Torr

6: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / 0 - 25 °C

7: acetonitrile / 20 °C

With 2,6-dimethylpyridine; sodium azide; oxalyl dichloride; trifluoromethylsulfonic anhydride; hydrogen; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 852661-68-8
(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

: 675122-49-3
phenyl 3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenylcarbamate

: 852661-64-4
N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: In acetonitrile; at 20 ℃;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852661-64-4
N-((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)-N'-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

3.2: 1 h

4.1: lithium trifluoromethanesulfonate / acetonitrile

5.1: methanol / 2 h / 20 °C / Molecular sieve

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

6.2: 0.5 h / 20 °C

7.1: acetonitrile / 20 °C

With lithium aluminium tetrahydride; hydrogen; lithium trifluoromethanesulfonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; acetonitrile;