methylenebisphosphonic acid P,P'-dicyclohexyl diester

Base Information

• Chemical Name: methylenebisphosphonic acid P,P'-dicyclohexyl diester
• CAS No.: 23501-59-9
• Molecular Formula: C₁₃H₂₆O₆P₂
• Molecular Weight: 340.293
• Mol file: 23501-59-9.mol

Synonyms:methylenebisphosphonic acid P,P'-dicyclohexyl diester

Chemical Property of methylenebisphosphonic acid P,P'-dicyclohexyl diester

Chemical Property:

Purity/Quality:

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Technology Process of methylenebisphosphonic acid P,P'-dicyclohexyl diester

There total 3 articles about methylenebisphosphonic acid P,P'-dicyclohexyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methylenebis(cyclohexyl methyl phosphonate) → methylenebisphosphonic acid P,P'-dicyclohexyl diester (23501-59-9)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)00846-8

Reference yield: 94.0%

P,P'-methanediyl-bis-phosphonic acid tetrachloride (1499-29-2) + cyclohexanol (108-93-0) → methylenebisphosphonic acid P,P'-dicyclohexyl diester (23501-59-9)

Guidance literature:

P,P'-methanediyl-bis-phosphonic acid tetrachloride; cyclohexanol; With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃;

With water; In toluene; for 0.25h;

DOI:10.1081/SCC-120006033

Reference yield:

cyclohexanol (108-93-0) → methylenebisphosphonic acid P,P'-dicyclohexyl diester (23501-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-tetrazole; iPr₂NEt / toluene / 20 °C

1.2: 85 percent / iPr₂NEt / toluene / 0.25 h

2.1: 94 percent / Me₃SiBr / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-tetrazole; trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)00846-8

upstream raw materials:

P,P'-methanediyl-bis-phosphonic acid tetrachloride

cyclohexanol