(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

Base Information

Chemical Name:(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester
CAS No.:1079398-45-0
Molecular Formula:C₂₁H₃₁NO₇
Molecular Weight:409.48
Hs Code.:

Synonyms:(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

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Chemical Property of (1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

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Technology Process of (1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

There total 9 articles about (1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1079398-44-9
C₇H₁₂O₅

: 1056675-43-4
(1R,S)-1-(3-(bromomethyl)phenyl)-1-(t-butoxycarbonylamino)ethane

: 1079398-45-0
(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

Guidance literature:: With tetrabutylammomium bromide; di(n-butyl)tin oxide; In toluene; at 90 ℃; Heating / reflux;

Reference yield:

: 1079398-63-2
methyl 5,6-di-O-benzyl-3-deoxy-D-glucofuranoside

: 1079398-45-0
(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 10.5 h / 0 - 20 °C

2: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

3: dipyridinium dichromate / dichloromethane / 12 h / 0 - 20 °C / Molecular sieve

4: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

5: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

With dipyridinium dichromate; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; sodium hydride; di(n-butyl)tin oxide; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1079398-42-7
C₂₂H₂₈O₅

: 1079398-45-0
(1R/S-{3-[2R-hydroxy-2R-(4R-methoxy-5-oxotetrahydrofuran-2S-yl)ethoxymethy]-phenyl}-ethyl)carbamic acid-tert-butylester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

2: dipyridinium dichromate / dichloromethane / 12 h / 0 - 20 °C / Molecular sieve

3: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / methanol; water / 12 h / 20 °C / 7355.72 Torr

4: tetrabutylammomium bromide; di(n-butyl)tin oxide / toluene / 90 °C / Heating / reflux

With dipyridinium dichromate; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; di(n-butyl)tin oxide; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; toluene;