tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate
CAS No.:1403595-86-7
Molecular Formula:C₃₁H₄₅N₅O₄
Molecular Weight:551.729
Hs Code.:

tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

Synonyms:tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

There total 7 articles about tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403595-86-7
tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / methanol / 2 h / 20 °C

3.2: 16 h / 20 °C

4.1: caesium carbonate / acetonitrile / 12 h / 80 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / 100 °C / Inert atmosphere

6.1: sodium hydroxide; water / methanol / 1 h / 60 °C

6.2: pH 4 - 6

7.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; iron; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403595-86-7
tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / methanol / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate / acetonitrile / 12 h / 80 °C

4.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; ethanol; water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403595-86-7
tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

1.2: Cooling

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

4.1: acetic acid / methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: caesium carbonate / acetonitrile / 12 h / 80 °C

6.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / 100 °C / Inert atmosphere

7.1: sodium hydroxide; water / methanol / 1 h / 60 °C

7.2: pH 4 - 6

8.1: dimethyl sulfoxide / 0.25 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;