triglutamate folate

Base Information

Chemical Name:triglutamate folate
CAS No.:29701-38-0
Molecular Formula:C₃₄H₄₀N₁₀O₁₅
Molecular Weight:828.75
Hs Code.:
Mol file:29701-38-0.mol

Synonyms:Glutamicacid, N-[N-[N-(N-pteroyl-L-g-glutamyl)-L-g-glutamyl]-L-g-glutamyl]-, L- (8CI); L-Glutamic acid,N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl-L-g-glutamyl- (9CI); L-Glutamicacid, N-[N-[N-[N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl]-L-g-glutamyl]-L-g-glutamyl]-; Folic acidtriglutamate; Pteroyl-L-glutamyl-g-L-glutamyl-g-L-glutamyl-g-L-glutamic acid;Pteroyltetraglutamic acid

Suppliers and Price of triglutamate folate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of triglutamate folate

Chemical Property:

Boiling Point:1196.5°Cat760mmHg
Flash Point:677.4°C
Density:1.7g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of triglutamate folate

There total 7 articles about triglutamate folate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 29701-38-0
folyl-tetra-γ-L-glutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

4: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

5: 0.1 N NaOH

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; KH polyamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 84793-07-7
Fmoc-Glu-OtBu

: 29701-38-0
folyl-tetra-γ-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

3: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

4: 0.1 N NaOH

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; KH polyamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 37793-53-6
N¹⁰-(trifluoroacetyl)pteroic acid

: 29701-38-0
folyl-tetra-γ-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylsulfoxide; dimethylformamide / 30 h / 0 °C

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

3: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

4: 0.1 N NaOH

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; KH polyamide resin; trifluoroacetic acid; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a038