{4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester

Base Information

• Chemical Name: {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester
• CAS No.: 1027265-65-1
• Molecular Formula: C₁₅H₁₄ClN₃O₃
• Molecular Weight: 319.747
• Mol file: 1027265-65-1.mol

Synonyms:{4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester

Chemical Property of {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester

There total 2 articles about {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloronicotinoyl chloride (49609-84-9) + N-(4-aminophenyl)carbamic acid ethyl ester (57399-97-0) → {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester (1027265-65-1)

Guidance literature:

With pyridine; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1021/jm00045a012

Reference yield:

2-chloronicotinic acid (2942-59-8) → {4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester (1027265-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 0.67 h / Heating

2: pyridine, DMF / CH₂Cl₂ / 1.5 h / 0 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm00045a012

Reference yield:

{4-[(2-Chloro-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester (1027265-65-1) → [4-(3-Oxo-3H-isothiazolo[5,4-b]pyridin-2-yl)-phenyl]-carbamic acid ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: KOtBu / 2-methyl-propan-2-ol / 2 h / Heating

2: m-CPBA / CHCl₃

3: 16 percent / pyridine / toluene / 0.5 h / Heating

With pyridine; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In chloroform; toluene; tert-butyl alcohol;

DOI:10.1021/jm00045a012

upstream raw materials:

2-Chloronicotinoyl chloride

N-(4-aminophenyl)carbamic acid ethyl ester

2-chloronicotinic acid

Downstream raw materials:

{4-[(2-tert-Butylsulfanyl-pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid ethyl ester

(4-{[2-(2-Methyl-propane-2-sulfinyl)-pyridine-3-carbonyl]-amino}-phenyl)-carbamic acid ethyl ester