4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

Base Information

Chemical Name:4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid
CAS No.:176375-52-3
Molecular Formula:C₄₀H₄₆N₂O₁₁
Molecular Weight:730.812
Hs Code.:

Synonyms:4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

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Chemical Property of 4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

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Technology Process of 4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

There total 7 articles about 4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 176375-46-5
4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid methyl ester

: 176375-52-3
4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; methanol; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(96)00053-1

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 176375-52-3
4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / K₂CO₃, Bu₄NI / acetonitrile / 17 h / Heating

2: 85 percent / HNO₃, AcOH / 6 h / Ambient temperature

3: 66 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

4: toluene; tetrahydrofuran / 3 h / Ambient temperature

5: iPr₂NEt / tetrahydrofuran / Ambient temperature

6: 41 percent / pyridine / 1 h / 50 °C

7: 89 percent / aq. LiOH / methanol; dioxane / 2 h / Ambient temperature

With pyridine; lithium hydroxide; sodium tetrahydroborate; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(96)00053-1

Reference yield:

: 176375-41-0
4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester

: 176375-52-3
4-(4-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxymethyl}-2-methoxy-5-nitro-phenoxy)-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / HNO₃, AcOH / 6 h / Ambient temperature

2: 66 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

3: toluene; tetrahydrofuran / 3 h / Ambient temperature

4: iPr₂NEt / tetrahydrofuran / Ambient temperature

5: 41 percent / pyridine / 1 h / 50 °C

6: 89 percent / aq. LiOH / methanol; dioxane / 2 h / Ambient temperature

With pyridine; lithium hydroxide; sodium tetrahydroborate; nitric acid; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene;
DOI:10.1016/S0040-4020(96)00053-1