6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester

Base Information

• Chemical Name: 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester
• CAS No.: 119348-56-0
• Molecular Formula: C₂₆H₃₀O₆
• Molecular Weight: 438.521

Synonyms:6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester

Chemical Property of 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester

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Technology Process of 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester

There total 4 articles about 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone (97582-36-0) + 6-hydroxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid ethyl ester (105806-38-0) → 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester (119348-56-0)

Guidance literature:

With potassium tert-butylate; sodium iodide; In ethanol; for 30h; Ambient temperature;

DOI:10.1021/jm00113a014

Reference yield: 76.0%

→ 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester (119348-56-0)

Guidance literature:

Reference yield:

6-methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid, ethyl ester (50558-96-8) → 6-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid, ethyl ester (119348-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / AlCl₃ / CH₂Cl₂ / 20 h / Heating

2: 76 percent / potassium t-butoxide, NaI / ethanol / 30 h / Ambient temperature

With aluminium trichloride; potassium tert-butylate; sodium iodide; In ethanol; dichloromethane;

DOI:10.1021/jm00113a014

upstream raw materials:

1-<4-(chloromethyl)-2-hydroxy-3-propylphenyl>ethanone

6-hydroxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid ethyl ester

6-methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid, ethyl ester

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Downstream raw materials:

6-<(4-acetyl-3-hydroxy-2-propylphenyl)-methoxy>-1,2,3,4-tetrahydro-N-<(2-methylphenyl)sulfonyl>-1-oxo-2-naphthaleneacetamide

6-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid

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