(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide
CAS No.:1395408-72-6
Molecular Formula:C₁₄H₁₆F₆N₂O₂S
Molecular Weight:390.35
Hs Code.:

Synonyms:(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Suppliers and Price of (S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Chemical Property:

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Technology Process of (S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

There total 7 articles about (S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1157849-50-7,1157849-51-8
C₆H₁₄N₂*(x)ClH

: 39234-86-1
3,5-bis(trifluoromethyl)benzenesulfonyl chloride

: 1395408-72-6
(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol302005f

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 1395408-72-6
(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 16.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 10.25 h / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; calcium chloride / ethanol / 4 h / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / Inert atmosphere

5: 16 h / 20 °C / Inert atmosphere

6: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

7: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; thionyl chloride; triethylamine; calcium chloride; In ethanol; dichloromethane; water;
DOI:10.1021/ol302005f

Reference yield:

: 162955-48-8,397246-12-7
[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

: 1395408-72-6
(S)-N-(1-methylpiperidine-3-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / Inert atmosphere

2: 16 h / 20 °C / Inert atmosphere

3: methanol; hydrogenchloride / water / 16 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; triethylamine; In dichloromethane; water;
DOI:10.1021/ol302005f