Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

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Chemical Name:Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester
CAS No.:844476-65-9
Molecular Formula:C₃₄H₅₉ClO₆SSi
Molecular Weight:659.443
Hs Code.:

Synonyms:Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

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Chemical Property of Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

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Technology Process of Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

There total 11 articles about Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3518-65-8
monochloromethanesulfonyl chloride

: 335595-99-8
(2S,3R,4E)-3-benzoyloxy-1-thexyldimethylsilyloxy-octadec-4-ene-2-ol

: 844476-65-9
Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

Guidance literature:: In pyridine; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(02)00201-X

Reference yield:

: 765-13-9
pentadec-1-yne

: 844476-65-9
Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1 h / Heating

1.2: tetrahydrofuran; diethyl ether / -40 - 20 °C

1.3: Candida antarctica lipase / cyclohexane / 20 - 40 °C

2.1: 0.78 g / LiAlH₄ / tetrahydrofuran / 5 h / 40 °C

3.1: 80 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

4.1: 60 percent aq. CF₃COOH / 3 h / 0 °C

5.1: 0.76 g / pyridine / 0 - 20 °C

6.1: 86 percent / pyridine / 2 h / 20 °C

With pyridine; lithium aluminium tetrahydride; ethylmagnesium bromide; trifluoroacetic acid; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane;
DOI:10.1016/S0957-4166(02)00201-X

Reference yield:

: 98-88-4
benzoyl chloride

: 844476-65-9
Benzoic acid (E)-(R)-1-{(R)-1-chloromethanesulfonyloxy-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 60 percent aq. CF₃COOH / 3 h / 0 °C

3: 0.76 g / pyridine / 0 - 20 °C

4: 86 percent / pyridine / 2 h / 20 °C

With pyridine; trifluoroacetic acid; In pyridine; dichloromethane;
DOI:10.1016/S0957-4166(02)00201-X