9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

Base Information

Chemical Name:9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one
CAS No.:219840-76-3
Molecular Formula:C₂₁H₁₆BrF₃N₄O₃
Molecular Weight:509.282
Hs Code.:

Synonyms:9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

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Chemical Property of 9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

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Technology Process of 9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

There total 6 articles about 9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 75-44-5
phosgene

: 219840-94-5
5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

: 219840-76-3
9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

Guidance literature:: In toluene; Heating;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 219840-76-3
9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / (Ph₃P)4Pd, 1M aq. Na₂CO₃ / benzene / Heating

2: 79 percent / diisopropylethylamine / dioxane / Heating

3: 69 percent / Fe, HOAc / methanol / Heating

4: 62 percent / toluene / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; toluene; benzene;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 392-83-6
o-trifluoromethylphenyl bromide

: 219840-76-3
9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / tetrahydrofuran

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethyl acetate; benzene

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; ethyl acetate

4: iron; acetic acid / methanol; ethyl acetate

5: toluene

With n-butyllithium; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; toluene; benzene;