5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

Base Information

Chemical Name:5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine
CAS No.:219840-94-5
Molecular Formula:C₂₀H₁₈BrF₃N₄O₂
Molecular Weight:483.288
Hs Code.:

Synonyms:5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

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Chemical Property of 5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

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Technology Process of 5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

There total 5 articles about 5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 219840-93-4
4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

: 219840-94-5
5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

Guidance literature:: With iron; acetic acid; In methanol; Heating;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 219840-94-5
5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / (Ph₃P)4Pd, 1M aq. Na₂CO₃ / benzene / Heating

2: 79 percent / diisopropylethylamine / dioxane / Heating

3: 69 percent / Fe, HOAc / methanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; benzene;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 392-83-6
o-trifluoromethylphenyl bromide

: 219840-94-5
5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethyl acetate; benzene

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; ethyl acetate

4: iron; acetic acid / methanol; ethyl acetate

With n-butyllithium; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; benzene;