2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

Base Information

Chemical Name:2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid
CAS No.:762254-52-4
Molecular Formula:C₂₂H₁₆N₂O₇
Molecular Weight:420.378
Hs Code.:

Synonyms:2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

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Chemical Property of 2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

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Technology Process of 2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

There total 6 articles about 2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 762254-27-3
benzyl 2-bromo-5-carbamoylbenzoate

: 101084-81-5
(3-carboxy-5-nitrophenyl)boronic acid

: 762254-52-4
2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

Guidance literature:: C₃₁H₂₉N₃O₂; With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; for 3h; under 760.051 Torr; Inert atmosphere;

With trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/jm401670x

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 762254-52-4
2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

3: potassium carbonate; dihydrogen peroxide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; potassium carbonate; potassium hydrogencarbonate; In N,N-dimethyl-formamide; 4: |Suzuki Coupling;
DOI:10.1021/jm401670x

Reference yield:

: 762254-25-1
2-bromo-5-iodobenzoic acid benzyl ester

: 762254-52-4
2'-(benzyloxycarbonyl)-4'-carbamoyl-5-nitrobiphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

2: potassium carbonate; dihydrogen peroxide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; potassium carbonate; In N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/jm401670x