1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide

Base Information

• Chemical Name: 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide
• CAS No.: 14791-09-4
• Molecular Formula: C₁₁H₁₂N₄S
• Molecular Weight: 232.309
• Mol file: 14791-09-4.mol

Synonyms:1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide

Chemical Property of 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide

There total 2 articles about 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-benzylidene thiosemicarbazide (1627-73-2) + acrylonitrile (107-13-1,25014-41-9) → 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide (14791-09-4)

Guidance literature:

With potassium hydroxide; In water; acetone; at 35 ℃; for 19h; regioselective reaction;

DOI:10.1080/00397911.2016.1257723

Reference yield:

benzaldehyde (100-52-7) → 1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide (14791-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: potassium hydroxide / acetone; water / 19 h / 35 °C

With potassium hydroxide; In ethanol; water; acetone;

DOI:10.1080/00397911.2016.1257723

Reference yield: 47.0%

1-(2-cyanoethyl)-2-[phenylmethylidene]-1-hydrazinecarbothioamide (14791-09-4) → 1-benzylidene thiosemicarbazide (1627-73-2) + 3-{1-(aminocarbothioyl)-2-[phenylmethylidene]hydrazino}propanamide

Guidance literature:

With potassium hydroxide; In ethanol; at 50 - 52 ℃; for 11h;

DOI:10.1080/00397911.2016.1257723

upstream raw materials:

1-benzylidene thiosemicarbazide

acrylonitrile

benzaldehyde

Downstream raw materials:

1-benzylidene thiosemicarbazide