3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

Base Information

Chemical Name:3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one
CAS No.:1356399-64-8
Molecular Formula:C₂₈H₁₈ClN₃O₂
Molecular Weight:463.923
Hs Code.:

Synonyms:3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

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Chemical Property of 3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

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Technology Process of 3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

There total 4 articles about 3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.8%

: 90-15-3
α-naphthol

: C₂₀H₁₆ClN₃O₂

: 1356399-64-8
3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 75 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.044

Reference yield:

: 1260093-46-6
C₃₁H₂₇N₂O₂P

: 1356399-64-8
3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 12 h / 45 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 75 °C / Inert atmosphere

With potassium carbonate; In dichloromethane; acetonitrile; 1: Aza-Wittig reaction;
DOI:10.1016/j.ejmech.2011.10.044

Reference yield:

: 163455-37-6
4-amino-2-methylquinoline-3-carboxylic acid ethyl ester

: 1356399-64-8
3-(4-chlorophenyl)-5-methyl-2-(naphthalen-1-yloxy)pyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hexachloroethane; triethylamine / dichloromethane / 24 h / 20 °C

2: dichloromethane / 12 h / 45 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 75 °C / Inert atmosphere

With hexachloroethane; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 2: Aza-Wittig reaction;
DOI:10.1016/j.ejmech.2011.10.044