methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

Base Information

Chemical Name:methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate
CAS No.:1142224-91-6
Molecular Formula:C₂₂H₂₄F₂O₃
Molecular Weight:374.428
Hs Code.:

Synonyms:methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

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Chemical Property of methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

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Technology Process of methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

There total 11 articles about methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1035690-56-2
2-(3-(difluoromethoxy)phenyl )-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1142224-89-2
methyl 3-(2,2-dimethyIcyclopentyl)-4-(trifluoromethylsulfonyloxy)benzoate

: 1142224-91-6
methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In N,N-dimethyl-formamide; at 75 ℃; for 16h; Inert atmosphere;

Reference yield:

: 176240-84-9
methyl 4-(benzyloxy)-3-bromobenzoate

: 1142224-91-6
methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 27.5 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 20 °C

4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

With dmap; potassium phosphate; hydrogen; triethylamine; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142224-91-6
methyl 3'-((difluoromethyl)oxy)-2-(2,2-dimethylcyclopentyl)-1,1'-biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 27.5 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 20 °C

4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 16 h / 75 °C / Inert atmosphere

With dmap; potassium phosphate; hydrogen; triethylamine; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;