(RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one

Base Information

• Chemical Name: (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one
• CAS No.: 1428885-17-9
• Molecular Formula: C₂₃H₃₃NO₂S
• Molecular Weight: 387.587

Synonyms:(RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one

Chemical Property of (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one

Chemical Property:

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Technology Process of (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one

There total 3 articles about (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methanol (67-56-1) + 7-thia-14-azadispiro[5.1.58·26]pentadec-14-ene + 2-(3-methylphenyl)acetyl chloride (13910-79-7) → (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one (1428885-17-9)

Guidance literature:

7-thia-14-azadispiro[5.1.5⁸·2⁶]pentadec-14-ene; 2-(3-methylphenyl)acetyl chloride; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

methanol; With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0032-1316829

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one (1428885-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia; sodium hydrogensulfide / dichloromethane / 0 - 20 °C

2.1: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydrogensulfide; ammonia; In dichloromethane;

DOI:10.1055/s-0032-1316829

Reference yield:

1-chlorocyclohexane-1-carbaldehyde (53627-10-4) → (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one (1428885-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia; sodium hydrogensulfide / dichloromethane / 0 - 20 °C

2.1: dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydrogensulfide; ammonia; In dichloromethane;

DOI:10.1055/s-0032-1316829

upstream raw materials:

methanol

2-(3-methylphenyl)acetyl chloride

cyclohexanone

1-chlorocyclohexane-1-carbaldehyde

Downstream raw materials:

(RS)-8′-methyl-6′,10b′-dihydro-5′H-dispiro[cyclohexane-1,1′-thiazolo[4,3-a]isoquinoline-3′,1′′-cyclohexan]-5′-one

(RS)-1-(15-hydroxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one

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