C₁₄H₁₆FN₃O

Base Information

Chemical Name:C₁₄H₁₆FN₃O
CAS No.:1085159-17-6
Molecular Formula:C₁₄H₁₆FN₃O
Molecular Weight:261.299
Hs Code.:

C<sub>14</sub>H<sub>16</sub>FN<sub>3</sub>O

Synonyms:C₁₄H₁₆FN₃O

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Chemical Property of C₁₄H₁₆FN₃O

Chemical Property:

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Technology Process of C₁₄H₁₆FN₃O

There total 9 articles about C₁₄H₁₆FN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400741-16-3
5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine

: 1085159-17-6
C₁₄H₁₆FN₃O

Guidance literature:: 5-[4-(4-fluoromethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-phenyl]-pyridin-2-ylamine; With hydrogenchloride; water; acetic acid; at 100 - 110 ℃; for 16h; Sealed tube;

With potassium hydroxide; In water; pH=13;

Reference yield:

: 119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0
(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

: 1085159-17-6
C₁₄H₁₆FN₃O

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: sulfuric acid / 18 h / 105 °C

4.2: 20 °C / pH 13

5.1: triethylamine / 1,1-dichloroethane / Reflux

6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere

9.1: hydrogenchloride; water; acetic acid / 16 h / 100 - 110 °C / Sealed tube

9.2: pH 13

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 8.1: Suzuki Coupling;

Reference yield:

: 4423-58-9
N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide

: 1085159-17-6
C₁₄H₁₆FN₃O

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sulfuric acid / 18 h / 105 °C

3.2: 20 °C / pH 13

4.1: triethylamine / 1,1-dichloroethane / Reflux

5.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

6.2: 20 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 90 °C / Inert atmosphere

8.1: hydrogenchloride; water; acetic acid / 16 h / 100 - 110 °C / Sealed tube

8.2: pH 13

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; water; hydrogen; potassium carbonate; acetic acid; triethylamine; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; toluene; 7.1: Suzuki Coupling;