6-Methoxy-3-methylbenzofuran

Base Information

• Chemical Name: 6-Methoxy-3-methylbenzofuran
• CAS No.: 29040-52-6
• Molecular Formula: C10H10 O2
• Molecular Weight: 162.188
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID201308742
• Nikkaji Number: J1.391.604G
• ChEMBL ID: CHEMBL4463387
• Mol file: 29040-52-6.mol

Synonyms:6-Methoxy-3-methylbenzofuran;29040-52-6;6-methoxy-3-methyl-Benzofuran;6-Methoxy-3-methyl-1-benzofuran;Benzofuran, 6-methoxy-3-methyl-;CHEMBL4463387;SCHEMBL10171847;6-Methoxy-3-methylbenzo[b]furan;DTXSID201308742;6-Methoxy-3-methyl-1-benzofuran #;MFCD15144094;AKOS024465068;BS-16442;CS-0152849;D82922;A876543

Chemical Property of 6-Methoxy-3-methylbenzofuran

Chemical Property:

• PSA: 22.37000
• LogP: 2.74980
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxy-3-methylbenzofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=COC2=C1C=CC(=C2)OC

Technology Process of 6-Methoxy-3-methylbenzofuran

There total 13 articles about 6-Methoxy-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(2-acetyl-5-methoxy-phenoxy)-acetic acid ethyl ester (13246-19-0) → 6-methoxy-3-methylbenzofuran (29040-52-6) + 6-methoxy-3-methyl-benzofuran-2-carboxylic acid (10410-29-4) + 8-Methoxy-benzo[b]oxepine-3,5-dione (77956-75-3)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; at 60 ℃; for 6h;

Reference yield: 59.0%

1-(3-methoxyphenoxy)propan-2-one (6437-63-4) → 6-methoxy-3-methylbenzofuran (29040-52-6)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2008.09.034

Reference yield: 55.0%

3-allyloxy-4-chloroanisole (898826-74-9) → 3-chloromethyl-2,3-dihydro-6-methoxybenzofuran + 6-methoxy-3-methylbenzofuran (29040-52-6)

Guidance literature:

With acetone; benzene; In ethyl acetate; at 20 ℃; for 16h; Further Variations:; Solvents; Reagents; time; Product distribution; UV-irradiation;

DOI:10.1002/chem.200501392

upstream raw materials:

1-(3-methoxyphenoxy)propan-2-one

(2-acetyl-5-methoxy-phenoxy)-acetic acid ethyl ester

sulfuric acid

3-allyloxy-4-chloroanisole

Downstream raw materials:

6-methoxy-3-methylbenzofuran-2-carbaldehyde

β-<6-Methoxy-3-methyl-2-benzofuryl>-propionsaeure

6-methoxy-3-methyl-benzofuran-2-carboxylic acid

ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate