(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

Base Information

Chemical Name:(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate
CAS No.:1621924-51-3
Molecular Formula:C₂HF₃O₂*C₁₇H₂₅FN₂O₃
Molecular Weight:438.419
Hs Code.:

Synonyms:(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

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Chemical Property of (2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

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Technology Process of (2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

There total 5 articles about (2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1621924-49-9
(2S,4S)-4-tert-butoxycarbonylamino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester

: 76-05-1
trifluoroacetic acid

: 1621924-51-3
(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

Guidance literature:: In dichloromethane; for 5h;

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 1621924-51-3
(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

4.1: 4-methyl-morpholine; isobutyl chloroformate / toluene / 1 h / 20 °C

5.1: dichloromethane / 5 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; potassium carbonate; lithium hexamethyldisilazane; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1621924-38-6
(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

: 1621924-51-3
(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

2: 4-methyl-morpholine; isobutyl chloroformate / toluene / 1 h / 20 °C

3: dichloromethane / 5 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; isobutyl chloroformate; In methanol; dichloromethane; toluene;