(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

Base Information

Chemical Name:(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester
CAS No.:1621924-38-6
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

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Chemical Property of (2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

Chemical Property:

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Technology Process of (2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

There total 2 articles about (2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 132245-78-4
(S)-2-tert-butoxycarbonylaminopentanedioic acid 1-benzyl ester 5-methyl ester

: 74-88-4
methyl iodide

: 1621924-38-6
(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

Guidance literature:: (S)-2-tert-butoxycarbonylaminopentanedioic acid 1-benzyl ester 5-methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 1621924-38-6
(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1621924-38-6
(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester

: 1621924-51-3
(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

2: 4-methyl-morpholine; isobutyl chloroformate / toluene / 1 h / 20 °C

3: dichloromethane / 5 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; isobutyl chloroformate; In methanol; dichloromethane; toluene;