(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

Base Information

Chemical Name:(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester
CAS No.:1621924-26-2
Molecular Formula:C₂₉H₃₈FN₃O₄
Molecular Weight:511.637
Hs Code.:

Synonyms:(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

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Chemical Property of (2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

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Technology Process of (2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

There total 6 articles about (2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 771-99-3
4-phenylpiperidine

: 74124-79-1
di(succinimido) carbonate

: 1621924-51-3
(2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate

: 1621924-26-2
(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

Guidance literature:: di(succinimido) carbonate; (2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 1h;

4-phenylpiperidine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 16h;

Reference yield:

: 132245-78-4
(S)-2-tert-butoxycarbonylaminopentanedioic acid 1-benzyl ester 5-methyl ester

: 1621924-26-2
(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

3.1: 4-methyl-morpholine; isobutyl chloroformate / toluene / 1 h / 20 °C

4.1: dichloromethane / 5 h

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 0 - 20 °C

5.2: 16 h / 0 - 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1621924-48-8
(2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 5-methyl ester

: 1621924-26-2
(2S,4S)-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methyl-4-[(4-phenylpiperidine-1-carbonyl)amino]butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / toluene / 1 h / 20 °C

2.1: dichloromethane / 5 h

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 0 - 20 °C

3.2: 16 h / 0 - 20 °C

With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In dichloromethane; toluene; acetonitrile;