5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide

Base Information

• Chemical Name: 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide
• CAS No.: 132532-33-3
• Molecular Formula: C₁₇H₂₂ClN₃O₂
• Molecular Weight: 335.834

Synonyms:5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide

Chemical Property of 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide

Chemical Property:

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Technology Process of 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide

There total 3 articles about 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide (132532-32-2) → 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide (132532-33-3)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1016/S0040-4020(01)81468-X

Reference yield:

4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)morpholine (42833-31-8) → 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide (132532-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / acetone / 2 h / Ambient temperature

2: 74 percent / N-chlorosuccinimide / CH₂Cl₂ / 2.5 h / 20 °C

With N-chloro-succinimide; In dichloromethane; acetone;

DOI:10.1016/S0040-4020(01)81468-X

Reference yield:

phenyl isocyanate (103-71-9) → 5-chloro-1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide (132532-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / acetone / 2 h / Ambient temperature

2: 74 percent / N-chlorosuccinimide / CH₂Cl₂ / 2.5 h / 20 °C

With N-chloro-succinimide; In dichloromethane; acetone;

DOI:10.1016/S0040-4020(01)81468-X

upstream raw materials:

1,2,3,6-tetrahydro-1-methyl-4-morpholino-N-phenyl-3-pyridinecarboxamide

4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)morpholine

phenyl isocyanate

Downstream raw materials:

5-morpholino-4-phenylimino-3,8-diazatricyclo<4.3.0.0^1.5>nonan-2-one

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