2(3H)-Benzoxazolone, 4-hydroxy-

Base Information

• Chemical Name: 2(3H)-Benzoxazolone, 4-hydroxy-
• CAS No.: 28955-70-6
• Molecular Formula: C7H5 N O3
• Molecular Weight: 151.122
• Mol file: 28955-70-6.mol

Synonyms:2-Benzoxazolinone,4-hydroxy- (6CI,8CI); 4-Hydroxy-2(3H)-benzoxazolone;4-Hydroxy-3H-benzoxazol-2-one

Chemical Property of 2(3H)-Benzoxazolone, 4-hydroxy-

Chemical Property:

• PSA: 66.23000
• LogP: 0.82670

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(3H)-Benzoxazolone, 4-hydroxy-

There total 5 articles about 2(3H)-Benzoxazolone, 4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

bis(trichloromethyl) carbonate (32315-10-9) + 2-aminoresorcinol (3163-15-3) → 4-hydroxybenzo[d]oxazol2(3H)-one (28955-70-6)

Guidance literature:

In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.cclet.2009.09.006

Reference yield: 69.5%

2-nitroresorcinol (601-89-8) + urea (57-13-6) → 4-hydroxybenzo[d]oxazol2(3H)-one (28955-70-6)

Guidance literature:

2-nitroresorcinol; With iron(III) chloride hexahydrate; hydrazine hexahydrate; pyrographite; In methanol; for 6h; Reflux;

urea; With acetic acid butyl ester; at 90 ℃; for 5h;

DOI:10.1155/2015/534156

Reference yield:

2-aminoresorcinol (3163-15-3) + 1,1'-carbonyldiimidazole (530-62-1) → 4-hydroxybenzo[d]oxazol2(3H)-one (28955-70-6)

Guidance literature:

In tetrahydrofuran; Heating / reflux;

upstream raw materials:

2-aminoresorcinol hydrochloride

urea

2-aminoresorcinol

1,1'-carbonyldiimidazole

Downstream raw materials:

4-[2-(tert-butoxycarbonylamino)3-phenyl]propionyloxy-2(3H)-benzoxazolone

Refernces

• 1、 Wang, Hongyuan,Wei, Xiugui,Wei, Xian,Sun, Xuemei,Huang, Xiukun,Liang, Yingqin,Xu, Wanpeng,Zhu, Xunshuai,Lin, Xing,Lin, Jun. "4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice". . . Retrieved 2020.
• 2、 Zheng, Guangjin,Chen, Tieyu,Peng, Xing,Long, Shengjing. "Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone". . . Retrieved 2015/08/03.